148821-01-6
Chemical Structure
MANT-GppNHp
- CAS No.: 148821-01-6
- Formula:C18H24N7O14P3
- Molecular Weight:655.35
IUPAC Name: (2R,3R,4R,5R)-2-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-4-hydroxy-5-(((hydroxy((hydroxy(phosphonoamino)phosphoryl)oxy)phosphoryl)oxy)methyl)tetrahydrofuran-3-yl 2-(methylamino)benzoate compound with (2R,3S,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-4-hydroxy-2-(((hydroxy((hydroxy(phosphonoamino)phosphoryl)oxy)phosphoryl)oxy)methyl)tetrahydrofuran-3-yl 2-(methylamino)benzoate (1:1)
InChIKey: UVGJXNOQPOTRQP-HFHOQTCASA-N
SMILES: O[C@@H]1[C@H](OC(C2=C(NC)C=CC=C2)=O)[C@@H](CO[P](O[P](N[P](O)(O)=O)(O)=O)(O)=O)O[C@H]1N3C(NC(N)=NC4=O)=C4N=C3.O=C5C6=C(NC(N)=N5)N([C@H]7[C@H](OC(C8=C(NC)C=CC=C8)=O)[C@H](O)[C@@H](CO[P](O[P](N[P](O)(O)=O)(O)=O)(O)=O)O7)C=N6
Biological Activity: MANT-GppNHp is a competitive adenyl cyclase (AC) inhibitor. MANT-GppNHp is a fluorescently labeled GTP (HY-113225) analogue. MANT-GppNHp interacts with the hydrophobic pocket near the AC catalytic site through its MANT group, thereby directly blocking the binding of the substrate ATP. MANT-GppNHp can be used to study diseases related to the increased activity of AC (such as cholera)[1].
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MANT-GppNHp | MANT-GppNHp is a competitive adenyl cyclase (AC) inhibitor. MANT-GppNHp is a fluorescently labeled GTP (HY-113225) analogue. MANT-GppNHp interacts with the hydrophobic pocket near the AC catalytic site through its MANT group, thereby directly blocking the binding of the substrate ATP. MANT-GppNHp can be used to study diseases related to the increased activity of AC (such as cholera). | |||||||||||||||||||||
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