149455-36-7
Chemical Structure
UR 8225
- CAS No.: 149455-36-7
- Formula:C18H14N2O2
- Molecular Weight:290.32
InChIKey: PJCGOKFHROWGBX-UHFFFAOYSA-N
SMILES: N#CC1=CC2=C(C(C(C)(C)C=C2N3C=CC=CC3=O)=O)C=C1
Biological Activity: UR 8225 is an orally active ATP-sensitive K+ channel activator with vasodilator, smooth muscle relaxant, antihypertensive, and bronchodilator activities. UR 8225 induces membrane hyperpolarization by increasing outward K+ conductance and reduces Ca2+ influx through voltage-gated L-type Ca2+ channels. UR 8225 reduces total peripheral vascular resistance, shortens cardiac action potential duration, inhibits agonist-induced Ca2+ influx, and stimulates renin release. UR 8225 induces reflex tachycardia but lacks β-adrenergic receptor blocking activity. UR 8225 is widely applicable to research in fields related to hypertension, myocardial ischemia, ventricular fibrillation, and other conditions[1][2].
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UR 8225 | UR 8225 is an orally active ATP-sensitive K+ channel activator with vasodilator, smooth muscle relaxant, antihypertensive, and bronchodilator activities. UR 8225 induces membrane hyperpolarization by increasing outward K+ conductance and reduces Ca2+ influx through voltage-gated L-type Ca2+ channels. UR 8225 reduces total peripheral vascular resistance, shortens cardiac action potential duration, inhibits agonist-induced Ca2+ influx, and stimulates renin release. UR 8225 induces reflex tachycardia but lacks β-adrenergic receptor blocking activity. UR 8225 is widely applicable to research in fields related to hypertension, myocardial ischemia, ventricular fibrillation, and other conditions. | |||||||||||||||||||||
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References
- [1]. Tamargo J, et al. Pharmacology of UR‐8225, a New Potassium Channel Opener[J]. Cardiovascular drug reviews, 1996, 14(3): 256-271.
- [2]. Perez-Vizcaino F, et al. Effects of the novel potassium channel opener, UR-8225, on contractile responses in rat isolated smooth muscle. Br J Pharmacol. 1993;110(3):1165-1171. [Content Brief]
