1496551-77-9
Chemical Structure
Uprifosbuvir
Synonym(s): IDX21437; MK-3682
- CAS No.: 1496551-77-9
- Formula:C22H29ClN3O9P
- Molecular Weight:545.91
IUPAC Name: isopropyl ((R)-(((2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alaninate
InChIKey: SFPFZQKYPOWCSI-KHFYHRBSSA-N
SMILES: C[C@]([C@@](N(C=CC1=O)C(N1)=O)([H])O[C@@H]2CO[P@@](OC3=CC=CC=C3)(N[C@H](C)C(OC(C)C)=O)=O)([C@@H]2O)Cl
Biological Activity: Uprifosbuvir (IDX21437; MK-3682) is a nucleotide analog inhibitor that inhibits YFV NS5 RNA-dependent RNA polymerase (RNA polymerase) and HCV NS5b. Uprifosbuvir can be used for research on yellow fever and chronic hepatitis C virus (HCV) infection[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Uprifosbuvir | 98.17% | Uprifosbuvir (IDX21437; MK-3682) is a nucleotide analog inhibitor that inhibits YFV NS5 RNA-dependent RNA polymerase (RNA polymerase) and HCV NS5b. Uprifosbuvir can be used for research on yellow fever and chronic hepatitis C virus (HCV) infection. | ||||||||||||||||||||
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References
- [1]. Binderup A, et al. Substitutions M478K and A482G in the polymerase of yellow fever virus confer resistance to sofosbuvir and uprifosbuvir in vitro. Antiviral research. 2026 May;249:106381. [Content Brief]
- [2]. Klapars A, et al. Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods. Chemical science. 2021 Jul 07;12(26):9031-9036. [Content Brief]
