2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. GS-9851

GS-9851 (PSI-7851) is a HCV nonstructural protein 5B (NS5B) inhibitor with potential activity for the study of HCV infection. GS-9851 shows good tolerability with initial HCV genotype 1 infection. GS-9851 is rapidly cleared from the body with a half-life of approximately 1 hour.

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GS-9851

GS-9851 Chemical Structure

CAS No. : 1064684-44-1

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GS-9851 Related Antibodies

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Description

GS-9851 (PSI-7851) is a HCV nonstructural protein 5B (NS5B) inhibitor with potential activity for the study of HCV infection. GS-9851 shows good tolerability with initial HCV genotype 1 infection. GS-9851 is rapidly cleared from the body with a half-life of approximately 1 hour[1].

Cellular Effect
Cell Line Type Value Description References
BXPC-3 CC50
> 100 μM
Compound: PSI-7851
Cytotoxicity against human BxPC3 cells assessed as effect on cellular GAPDH RNA level after 8 days by quantitative real-time PCR
Cytotoxicity against human BxPC3 cells assessed as effect on cellular GAPDH RNA level after 8 days by quantitative real-time PCR
[PMID: 20516278]
CCRF-CEM CC50
> 100 μM
Compound: PSI-7851
Cytotoxicity against human CEM cells assessed as effect on cellular GAPDH RNA level after 8 days by quantitative real-time PCR
Cytotoxicity against human CEM cells assessed as effect on cellular GAPDH RNA level after 8 days by quantitative real-time PCR
[PMID: 20516278]
HFF CC50
> 100 μM
Compound: PSI-7851
Cytotoxicity against HFF
Cytotoxicity against HFF
[PMID: 20516278]
HFF CC50
> 100 μM
Compound: PSI-7851
Cytotoxicity against HFF
Cytotoxicity against HFF
[PMID: 20516278]
HFF CC50
> 100 μM
Compound: PSI-7851
Cytotoxicity against HFF
Cytotoxicity against HFF
[PMID: 20516278]
HFF CC50
> 100 μM
Compound: PSI-7851
Cytotoxicity against HFF
Cytotoxicity against HFF
[PMID: 20516278]
HFF CC50
> 100 μM
Compound: PSI-7851
Cytotoxicity against HFF
Cytotoxicity against HFF
[PMID: 20516278]
HepG2 CC50
> 100 μM
Compound: PSI-7851
Cytotoxicity against human HepG2 cells assessed as effect on cellular GAPDH RNA level after 8 days by quantitative real-time PCR
Cytotoxicity against human HepG2 cells assessed as effect on cellular GAPDH RNA level after 8 days by quantitative real-time PCR
[PMID: 20516278]
Huh-7 CC50
> 100 μM
Compound: 48
Cytotoxicity against human HuH7 cells infected with HCV con1 subgenomic replicon assessed as reduction in cell viability measured after 3 days by CellTiter-blue cell viability assay
Cytotoxicity against human HuH7 cells infected with HCV con1 subgenomic replicon assessed as reduction in cell viability measured after 3 days by CellTiter-blue cell viability assay
[PMID: 30951311]
Huh-7 CC50
> 100 μM
Compound: PSI-7851
Cytotoxicity against human HuH7 cells assessed as effect on cellular GAPDH RNA level after 8 days by quantitative real-time PCR
Cytotoxicity against human HuH7 cells assessed as effect on cellular GAPDH RNA level after 8 days by quantitative real-time PCR
[PMID: 20516278]
Molecular Weight

529.45

Formula

C22H29FN3O9P
CAS No.
SMILES

F[C@]1(C)[C@H](O)[C@@H](COP(N[C@H](C(OC(C)C)=O)C)(OC2=CC=CC=C2)=O)O[C@H]1N3C(NC(C=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GS-9851 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GS-98511064684-44-1PSI-7851GS9851GS 9851PSI7851PSI 7851Endogenous MetaboliteInhibitorinhibitorinhibit

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