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Cat. No.: HY-14308

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GS-9851

(Synonyms: PSI-7851)

GS-9851 (PSI-7851) is a HCV nonstructural protein 5B (NS5B) inhibitor with potential activity for the study of HCV infection. GS-9851 shows good tolerability with initial HCV genotype 1 infection. GS-9851 is rapidly cleared from the body with a half-life of approximately 1 hour.

For research use only. We do not sell to patients.

CAS No.: 1064684-44-1
Formula: C₂₂H₂₉FN₃O₉P
Molecular Weight:529.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

GS-9851 Chemical Structure

CAS No.: 1064684-44-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	CC₅₀	>100 μM Compound: PSI-7851	Cytotoxicity against human BxPC3 cells assessed as effect on cellular GAPDH RNA level after 8 days by quantitative real-time PCR Cytotoxicity against human BxPC3 cells assessed as effect on cellular GAPDH RNA level after 8 days by quantitative real-time PCR	[PMID: 20516278]
CCRF-CEM	CC₅₀	>100 μM Compound: PSI-7851	Cytotoxicity against human CEM cells assessed as effect on cellular GAPDH RNA level after 8 days by quantitative real-time PCR Cytotoxicity against human CEM cells assessed as effect on cellular GAPDH RNA level after 8 days by quantitative real-time PCR	[PMID: 20516278]
HepG2	CC₅₀	>100 μM Compound: PSI-7851	Cytotoxicity against human HepG2 cells assessed as effect on cellular GAPDH RNA level after 8 days by quantitative real-time PCR Cytotoxicity against human HepG2 cells assessed as effect on cellular GAPDH RNA level after 8 days by quantitative real-time PCR	[PMID: 20516278]
HFF	CC₅₀	>100 μM Compound: PSI-7851	Cytotoxicity against HFF Cytotoxicity against HFF	[PMID: 20516278]
Huh-7	CC₅₀	>100 μM Compound: 48	Cytotoxicity against human HuH7 cells infected with HCV con1 subgenomic replicon assessed as reduction in cell viability measured after 3 days by CellTiter-blue cell viability assay Cytotoxicity against human HuH7 cells infected with HCV con1 subgenomic replicon assessed as reduction in cell viability measured after 3 days by CellTiter-blue cell viability assay	[PMID: 30951311]
Huh-7	CC₅₀	>100 μM Compound: PSI-7851	Cytotoxicity against human HuH7 cells assessed as effect on cellular GAPDH RNA level after 8 days by quantitative real-time PCR Cytotoxicity against human HuH7 cells assessed as effect on cellular GAPDH RNA level after 8 days by quantitative real-time PCR	[PMID: 20516278]

Chemical Information

CAS No. 1064684-44-1
Molecular Weight 529.45
Formula C₂₂H₂₉FN₃O₉P
SMILES

F[C@]1(C)[C@H](O)[C@@H](COP(N[C@H](C(OC(C)C)=O)C)(OC2=CC=CC=C2)=O)O[C@H]1N3C(NC(C=C3)=O)=O
Synonyms

PSI-7851
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pharmacokinetics, pharmacodynamics, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor, following multiple ascending doses in patients with chronic hepatitis C infection

[2]. Discovery of a β-D-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus J. Med. Chem., Article ASAP DOI: 10.1021/jm100863x Publication Date (Web): September 16, 2010

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
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Purity & Documentation
References

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GS-9851

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

GS-9851 Related Classifications

HY-14308 Related Classifications