149838-23-3
Chemical Structure
Doranidazole
Synonym(s): PR 350; RP 343
- CAS No.: 149838-23-3
- Formula:C8H13N3O6
- Molecular Weight:247.21
IUPAC Name: (2S,3R)-3-((2-nitro-1H-imidazol-1-yl)methoxy)butane-1,2,4-triol
InChIKey: FIITXXIVUIXYMI-NKWVEPMBSA-N
SMILES: OC[C@H](O)[C@@H](CO)OCN1C([N+]([O-])=O)=NC=C1
Biological Activity: Doranidazole (PR 350) is a radiosensitizer. Doranidazole increases the radiosensitivity of hypoxic SCCVII cells. Doranidazole significantly enhances radiation-induced growth delay in SCCVII tumors when administered intravenously before tumor irradiation. Doranidazole radiosensitizes tumors to an extent that depends on the tumor's oxygenation status. Doranidazole can be used for the study of lymphoma and hypoxic pancreatic tumors[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Doranidazole | Doranidazole (PR 350) is a radiosensitizer. Doranidazole increases the radiosensitivity of hypoxic SCCVII cells. Doranidazole significantly enhances radiation-induced growth delay in SCCVII tumors when administered intravenously before tumor irradiation. Doranidazole radiosensitizes tumors to an extent that depends on the tumor's oxygenation status. Doranidazole can be used for the study of lymphoma and hypoxic pancreatic tumors. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Yahiro T, et al. Effects of hypoxic cell radiosensitizer doranidazole (PR-350) on the radioresponse of murine and human tumor cells in vitro and in vivo. J Radiat Res. 2005 Sep;46(3):363-72. [Content Brief]
- [2]. Mizuho Aoki, et al. Effect of a Hypoxic Cell Sensitizer Doranidazole on the Radiation-induced Apoptosis of Mouse L5178Y Lymphoma Cells, Journal of Radiation Research, Volume 43, Issue 2, June 2002, Pages 161–166.
- [3]. Shibamoto Y, et al. Radiosensitivity of human pancreatic cancer cells in vitro and in vivo, and the effect of a new hypoxic cell sensitizer, doranidazole. Radiother Oncol. 2000 Aug;56(2):265-70. [Content Brief]
Keywords
