153608-99-2
Chemical Structure
YM114
Synonym(s): KAE-393
- CAS No.: 153608-99-2
- Formula:C16H18ClN3O
- Molecular Weight:303.79
IUPAC Name: (R)-indolin-1-yl(4,5,6,7-tetrahydro-1H-benzo[d]imidazol-6-yl)methanone hydrochloride
InChIKey: GZXONPGTMHLBKQ-UTONKHPSSA-N
SMILES: O=C([C@H]1CC2=C(N=CN2)CC1)N3C4=CC=CC=C4CC3.Cl
Biological Activity: YM114 (KAE-393) is a highly potent and selective (5-HT)3-receptor antagonist that does not affect Veratridine (HY-N6691)- or electrical stimulation-induced bradycardia in anesthetized rats. YM114 inhibits 2-methyl-5-HT (HY-19358)-induced Bezold-Jarisch reflex, which originates from (5-HT)3-receptor located on the endings of vagal afferent nerves in the heart[1].
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YM114 | YM114 (KAE-393) is a highly potent and selective (5-HT)3-receptor antagonist that does not affect Veratridine (HY-N6691)- or electrical stimulation-induced bradycardia in anesthetized rats. YM114 inhibits 2-methyl-5-HT (HY-19358)-induced Bezold-Jarisch reflex, which originates from (5-HT)3-receptor located on the endings of vagal afferent nerves in the heart. | |||||||||||||||||||||
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References
- [1]. Yamano M, et al. Characteristics of inhibitory effects of serotonin (5-HT)3-receptor antagonists, YM060 and YM114 (KAE-393), on the von Bezold-Jarisch reflex induced by 2-Methyl-5-HT, veratridine and electrical stimulation of vagus nerves in anesthetized rats. Jpn J Pharmacol. 1995 Dec;69(4):351-6. [Content Brief]
