154040-19-4
Chemical Structure
α-Synuclein (61-95) (human)
- CAS No.: 154040-19-4
- Formula:C141H235N39O49
- Molecular Weight:3260.61
SMILES: [C@H](CC1=CC=CC=C1)(C(N[C@@H](C(C)C)C(O)=O)=O)NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)N)=O)CCC(N)=O)=O)[C@H](C)C)=O)[C@@H](C)O)=O)CC(N)=O)=O)[C@H](C)C)=O)=O)=O)C)=O)[C@H](C)C)=O)C(C)C)=O)[C@@H](C)O)=O)=O)[C@H](C)C)=O)[C@@H](C)O)=O)C)=O)[C@H](C)C)=O)C)=O)CCC(N)=O)=O)CCCCN)=O)[C@@H](C)O)=O)C(C)C)=O)CCC(O)=O)=O)=O)C)=O)=O)CO)=O)[C@H](CC)C)=O)C)=O)C)=O)C)=O)[C@@H](C)O)=O)=O
Biological Activity: α-Synuclein (61-95) (human) is the hydrophobic core region of α-synuclein, and induces neuronal cell death. α-Synuclein (61-95) (human) can be used for research of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD)[1][2].
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α-Synuclein (61-95) (human) | α-Synuclein (61-95) (human) is the hydrophobic core region of α-synuclein, and induces neuronal cell death. α-Synuclein (61-95) (human) can be used for research of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). | |||||||||||||||||||||
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[U-15N]-α-Synuclein | [U-15N]-α-Synuclein is the 15N-labeled α-Synuclein. Abnormal levels and aggregation of α-synuclein in the brain are considered key factors in the pathogenesis of Parkinson's disease. This isotope can be used in NMR studies to investigate disease mechanisms and in mass spectrometry analysis. | |||||||||||||||||||||
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- [1]. Tabner BJ, et al. Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease. Free Radic Biol Med. 2002 Jun 1;32(11):1076-83. [Content Brief]
- [2]. Emadi S, et al. Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments. Biochemistry. 2004 Mar 16;43(10):2871-8.
