1542066-74-9
1542066-74-9
Chemical Structure
p53-MDM2-IN-3
- CAS No.: 1542066-74-9
- Formula:C30H25BrFN5O
- Molecular Weight:570.45
IUPAC Name: 5-(3-(1H-imidazol-1-yl)propyl)-4-(4-bromophenyl)-1-(4-fluorobenzyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one
InChIKey: WBTRUQGSTZSFSK-UHFFFAOYSA-N
SMILES: O=C1C2=C(C(N1CCCN3C=NC=C3)C4=CC=C(C=C4)Br)C(C5=CC=CC=C5)=NN2CC6=CC=C(C=C6)F
Biological Activity: p53-MDM2-IN-3 (Compound 5s) is an orally active p53-MDM2 inhibitor with a Ki value of 0.25 μM. p53-MDM2-IN-3 exerts antitumor activity by inhibiting NF-κB pathway[1].
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p53-MDM2-IN-3 | p53-MDM2-IN-3 (Compound 5s) is an orally active p53-MDM2 inhibitor with a Ki value of 0.25 μM. p53-MDM2-IN-3 exerts antitumor activity by inhibiting NF-κB pathway. | |||||||||||||||||||||
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References
Keywords
