p53-MDM2-IN-3
p53-MDM2-IN-3 (Compound 5s) is an orally active p53-MDM2 inhibitor with a Ki value of 0.25 μM. p53-MDM2-IN-3 exerts antitumor activity by inhibiting NF-κB pathway.
For research use only. We do not sell to patients.
- CAS No.: 1542066-74-9
- Formula: C30H25BrFN5O
- Molecular Weight:570.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
p53-MDM2-IN-3 (0.1-20 μM, 4 h) dose-dependent increases p65 levels in A549 cytoplasm and nucleus[1].
p53-MDM2-IN-3 (0.1-10 μM, 4 h) selectively activates p53 or inhibits the NF-κB pathway in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549
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Concentration:0.1, 1, 10 μM
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Incubation Time:4 h
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Result:Activated the phosphorylation of IKKβ only or both IKKβ and IKKα in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1542066-74-9
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Molecular Weight 570.45
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Formula C30H25BrFN5O
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SMILES
O=C1C2=C(C(N1CCCN3C=NC=C3)C4=CC=C(C=C4)Br)C(C5=CC=CC=C5)=NN2CC6=CC=C(C=C6)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
p53-MDM2-IN-3 Related Classifications
HY-121893 Related Classifications
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