p53-MDM2-IN-3
Based on 1 Customer Validation
p53-MDM2-IN-3 (Compound 5s) is an orally active p53-MDM2 inhibitor with a Ki value of 0.25 μM. p53-MDM2-IN-3 exerts antitumor activity by inhibiting NF-κB pathway.
For research use only. We do not sell to patients.
- Purity : 99.90%
- CAS No.: 1542066-74-9
- Formula: C30H25BrFN5O
- Molecular Weight:570.45
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
p53-MDM2-IN-3 (0.1-20 μM, 4 h) dose-dependent increases p65 levels in A549 cytoplasm and nucleus[1].
p53-MDM2-IN-3 (0.1-10 μM, 4 h) selectively activates p53 or inhibits the NF-κB pathway in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549
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Concentration:0.1, 1, 10 μM
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Incubation Time:4 h
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Result:Activated the phosphorylation of IKKβ only or both IKKβ and IKKα in a dose-dependent manner.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1542066-74-9
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Appearance Solid
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Molecular Weight 570.45
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Formula C30H25BrFN5O
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Color Light yellow to yellow
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SMILES
O=C1C2=C(C(N1CCCN3C=NC=C3)C4=CC=C(C=C4)Br)C(C5=CC=CC=C5)=NN2CC6=CC=C(C=C6)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 20 mg/mL (35.06 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7530 mL | 8.7650 mL | 17.5300 mL | 43.8250 mL |
| 5 mM | 0.3506 mL | 1.7530 mL | 3.5060 mL | 8.7650 mL | |
| 10 mM | 0.1753 mL | 0.8765 mL | 1.7530 mL | 4.3825 mL | |
| 15 mM | 0.1169 mL | 0.5843 mL | 1.1687 mL | 2.9217 mL | |
| 20 mM | 0.0877 mL | 0.4383 mL | 0.8765 mL | 2.1913 mL | |
| 25 mM | 0.0701 mL | 0.3506 mL | 0.7012 mL | 1.7530 mL | |
| 30 mM | 0.0584 mL | 0.2922 mL | 0.5843 mL | 1.4608 mL |
p53-MDM2-IN-3 Related Classifications
HY-121893 Related Classifications
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