15486-34-7
Chemical Structure
Kaempferol 3,7,4'-trimethyl ether
- CAS No.: 15486-34-7
- Formula:C18H16O6
- Molecular Weight:328.32
IUPAC Name: 5-hydroxy-3,7-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
InChIKey: WSQWAMGRHJQANC-UHFFFAOYSA-N
SMILES: COC1=C(C2=CC=C(OC)C=C2)OC3=CC(OC)=CC(O)=C3C1=O
Biological Activity: Kaempferol 3,7,4'-trimethyl ether is an O-methylated kaempferol flavonol aglycone distributed in Siparuna gigantotepala, Aframomum arundinaceum and Siparuna guianensis. Kaempferol 3,7,4'-trimethyl ether exhibits antioxidant activity. Kaempferol 3,7,4'-trimethyl ether suppresses the proliferation of leukemia cells and exerts selective cytotoxicity against both drug‑sensitive and multi‑factorial drug‑resistant cancer cells. Kaempferol 3,7,4'-trimethyl ether can be applied in the research of multidrug‑resistant cancers[1][2][3].
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Kaempferol 3,7,4'-trimethyl ether | 99.97% | Kaempferol 3,7,4'-trimethyl ether is an O-methylated kaempferol flavonol aglycone distributed in Siparuna gigantotepala, Aframomum arundinaceum and Siparuna guianensis. Kaempferol 3,7,4'-trimethyl ether exhibits antioxidant activity. Kaempferol 3,7,4'-trimethyl ether suppresses the proliferation of leukemia cells and exerts selective cytotoxicity against both drug‑sensitive and multi‑factorial drug‑resistant cancer cells. Kaempferol 3,7,4'-trimethyl ether can be applied in the research of multidrug‑resistant cancers. | ||||||||||||||||||||
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- [1]. Torres Castañeda HG, et al. Flavonoid Glycosides from Siparuna gigantotepala Leaves and Their Antioxidant Activity. Chem Pharm Bull (Tokyo). 2016;64(5):502-506. [Content Brief]
- [2]. Kuete V, et al. Cytotoxicity of four Aframomum species (A. arundinaceum, A. alboviolaceum, A. kayserianum and A. polyanthum) towards multi-factorial drug resistant cancer cell lines. BMC Complement Altern Med. 2014;14:340. Published 2014 Sep 19. [Content Brief]
- [3]. Facundo V, et al.Chemical constituents from three medicinal plants: Piper renitens, Siparuna guianensis and Alternanthera brasiliana.Rev Bras Farmacogn. 2012;22(5):1134-1139.
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