155204-81-2
Chemical Structure
DX-9065a
- CAS No.: 155204-81-2
- Formula:C26H39ClN4O8
- Molecular Weight:571.06
IUPAC Name: (S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-(4-(((S)-1-(1-iminoethyl)pyrrolidin-3-yl)oxy)phenyl)propanoic acid hydrochloride pentahydrate
InChIKey: LJCBAPRMNYSDOP-LVCYMWGESA-N
SMILES: N=C(N)C1=CC=C2C(C=C(C[C@H](C(O)=O)C3=CC=C(O[C@@H]4CN(C(C)=N)CC4)C=C3)C=C2)=C1.O.O.O.O.O.Cl
Biological Activity: DX-9065a is a selective, nonpeptidic, and orally active factor Xa (FXa) inhibitor with a Ki of 41 nM for human FXa. DX-9065a has low activity against other serine proteases. DX-9065a has strong anticoagulant actions[1][2].
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DX-9065a | DX-9065a is a selective, nonpeptidic, and orally active factor Xa (FXa) inhibitor with a Ki of 41 nM for human FXa. DX-9065a has low activity against other serine proteases. DX-9065a has strong anticoagulant actions. | |||||||||||||||||||||
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- [1]. Brigitte Kaiser. DX-9065a, a direct inhibitor of factor Xa. Cardiovasc Drug Rev. 2003 Summer;21(2):91-104. [Content Brief]
- [2]. J M Herbert, et al. DX 9065A a novel, synthetic, selective and orally active inhibitor of factor Xa: in vitro and in vivo studies. J Pharmacol Exp Ther. 1996 Mar;276(3):1030-8. [Content Brief]
Keywords
