155289-31-9
155289-31-9
Chemical Structure
1192U90
- CAS No.: 155289-31-9
- Formula:C22H27N5OS
- Molecular Weight:409.55
IUPAC Name: 2-amino-N-(4-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)butyl)benzamide
InChIKey: GMDXHLCLNHCEIC-UHFFFAOYSA-N
SMILES: O=C(C1=C(C=CC=C1)N)NCCCCN2CCN(C3=NSC4=C3C=CC=C4)CC2
Biological Activity: 1192U90 is an antipsychotic agent, dopamine D2 receptor antagonist as well as serotonin 5-HT1a receptor agonist. 1192U90 reduces the number of spontaneously firing neurons in the limbic dopamine system[1][2].
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1192U90 | 1192U90 is an antipsychotic agent, dopamine D2 receptor antagonist as well as serotonin 5-HT1a receptor agonist. 1192U90 reduces the number of spontaneously firing neurons in the limbic dopamine system. | |||||||||||||||||||||
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References
- [1]. Dillberger JE, et al. The experimental antipsychotic agent 1192U90 targets tapetum lucidum in canine eyes. Toxicol Pathol. 1996 Sep-Oct;24(5):595-601. [Content Brief]
- [2]. Norman MH, et al. Structure-activity relationships of a series of substituted benzamides: potent D2/5-HT2 antagonists and 5-HT1a agonists as neuroleptic agents. J Med Chem. 1996 Mar 1;39(5):1172-88. [Content Brief]
