1564253-75-3
1564253-75-3
Chemical Structure
PGN36
- CAS. Nr.: 1564253-75-3
- Formula:C21H23N3O3
- Molecular Weight:365.43
IUPAC Name: 1-benzyl-3-(cyclohexylmethoxy)-5-nitro-1H-indazole
InChIKey: VLMJWSVJQMZYSE-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC2=C(N(CC3=CC=CC=C3)N=C2OCC4CCCCC4)C=C1)[O-]
Biological Activity: PGN36 is a selective cannabinoid CB2 receptor (CB2R) antagonist with Kis of 0.09 µM and >40 µM for CB2R and CB1R, respectively. PGN36 abolishes the increase in collagen type I gene expression by the inducer of bone activity. PGN36 is able to cross the blood-brain barrier. PGN36 can be used for the study of frontotemporal dementia (FTD)[1][2].
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PGN36 | 99.59% | PGN36 is a selective cannabinoid CB2 receptor (CB2R) antagonist with Kis of 0.09 µM and >40 µM for CB2R and CB1R, respectively. PGN36 abolishes the increase in collagen type I gene expression by the inducer of bone activity. PGN36 is able to cross the blood-brain barrier. PGN36 can be used for the study of frontotemporal dementia (FTD). | ||||||||||||||||||||
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References
- [1]. González-Naranjo P, et al. New cannabinoid receptor antagonists as pharmacological tool. Bioorg Med Chem. 2020 Oct 1;28(19):115672. [Content Brief]
- [2]. Silva-Llanes I, et al. Targeting CB2 receptor with a novel antagonist reverses cognitive decline, neurodegeneration and pyroptosis in a TAU-dependent frontotemporal dementia mouse model. Brain Behav Immun. 2025 Mar 11;127:251-268. [Content Brief]
