157659-79-5
Chemical Structure
SB-209670
- CAS No.: 157659-79-5
- Formula:C29H28O9
- Molecular Weight:520.53
IUPAC Name: (1S,2R,3S)-1-(benzo[d][1,3]dioxol-5-yl)-3-(2-(carboxymethoxy)-4-methoxyphenyl)-5-propoxy-2,3-dihydro-1H-indene-2-carboxylic acid
InChIKey: UUAVCCWBNUITBB-UPRLRBBYSA-N
SMILES: O=C([C@@H]1[C@@H](C2=CC=C(OCO3)C3=C2)C4=C(C=C(OCCC)C=C4)[C@H]1C5=CC=C(OC)C=C5OCC(O)=O)O
Biological Activity: SB-209670 is an extremely potent and highly specific non-peptide, subnanomolar endothelin (ET) receptor antagonist. SB 209670 selectively inhibits binding of 125I-labeled ET-1 to cloned human ET receptor subtypes ETA and ETB (Ki=0.2 and 18 nM, respectively). SB 209670 produces a dose-dependent reduction in blood pressure in hypertensive rats, protects from ischemia-induced neuronal degeneration in a gerbil stroke model, and attenuates neointima formation following rat carotid artery balloon angioplasty[1].
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SB-209670 | SB-209670 is an extremely potent and highly specific non-peptide, subnanomolar endothelin (ET) receptor antagonist. SB 209670 selectively inhibits binding of 125I-labeled ET-1 to cloned human ET receptor subtypes ETA and ETB (Ki=0.2 and 18 nM, respectively). SB 209670 produces a dose-dependent reduction in blood pressure in hypertensive rats, protects from ischemia-induced neuronal degeneration in a gerbil stroke model, and attenuates neointima formation following rat carotid artery balloon angioplasty. | |||||||||||||||||||||
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Keywords
