1577222-14-0
Chemical Structure
Diroximel fumarate
Synonym(s): ALKS 8700; BIIB098
- CAS No.: 1577222-14-0
- Formula:C11H13NO6
- Molecular Weight:255.22
IUPAC Name: 2-(2,5-dioxopyrrolidin-1-yl)ethyl methyl fumarate
InChIKey: YIMYDTCOUQIDMT-SNAWJCMRSA-N
SMILES: O=C(OCCN1C(CCC1=O)=O)/C=C/C(OC)=O
Biological Activity: Diroximel fumarate (ALKS 8700) is an orally-active and well-tolerated monomethyl fumarate (MMF) proagent in a controlled-release formulation. Diroximel fumarate is considered as active equivalent to its active metabolite dimethyl fumarate (DMF). Diroximel fumarate has a favorable safety and efficacy profile, has the potential for the study of multiple sclerosis (MS). Diroximel fumarate is a Nrf2 activator that alleviate MGO-induced pain hypersensitivity[1][2].
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Diroximel fumarate | 99.60% | Diroximel fumarate (ALKS 8700) is an orally-active and well-tolerated monomethyl fumarate (MMF) proagent in a controlled-release formulation. Diroximel fumarate is considered as active equivalent to its active metabolite dimethyl fumarate (DMF). Diroximel fumarate has a favorable safety and efficacy profile, has the potential for the study of multiple sclerosis (MS). Diroximel fumarate is a Nrf2 activator that alleviate MGO-induced pain hypersensitivity. | ||||||||||||||||||||
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Diroximel fumarate (Standard) | ≥98% | Diroximel fumarate (Standard) is the analytical standard of Diroximel fumarate (HY-100375). This product is intended for research and analytical applications. Diroximel fumarate (ALKS 8700) is an orally-active and well-tolerated monomethyl fumarate (MMF) proagent in a controlled-release formulation. Diroximel fumarate is considered as active equivalent to its active metabolite dimethyl fumarate (DMF). Diroximel fumarate has a favorable safety and efficacy profile, has the potential for the study of multiple sclerosis (MS). Diroximel fumarate is a Nrf2 activator that alleviate MGO-induced pain hypersensitivity. | ||||||||||||||||||||
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References
- [1]. Angela Wehr, et al. Relative Bioavailability of Monomethyl Fumarate after Administration of ALKS 8700 in Healthy Subjects (P1.403). Neurology. Apr 2018.
- [2]. Yousuf MS, et al. Diroximel fumarate acts through Nrf2 to attenuate methylglyoxal-induced nociception in mice and decreases ISR activation in DRG neurons. bioRxiv [Preprint]. 2023 Dec 23:2023.12.22.572877. [Content Brief]
