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Cat. No.: HY-100375R

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Diroximel fumarate (Standard)

(Synonyms: ALKS 8700 (Standard); BIIB098 (Standard))

Diroximel fumarate (Standard) is the analytical standard of Diroximel fumarate (HY-100375). This product is intended for research and analytical applications. Diroximel fumarate (ALKS 8700) is an orally-active and well-tolerated monomethyl fumarate (MMF) proagent in a controlled-release formulation. Diroximel fumarate is considered as active equivalent to its active metabolite dimethyl fumarate (DMF). Diroximel fumarate has a favorable safety and efficacy profile, has the potential for the study of multiple sclerosis (MS). Diroximel fumarate is a Nrf2 activator that alleviate MGO-induced pain hypersensitivity.

For research use only. We do not sell to patients.

Purity: 95%
CAS No.: 1577222-14-0
Formula: C₁₁H₁₃NO₆
Molecular Weight:255.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Diroximel fumarate (Standard) Chemical Structure

CAS No.: 1577222-14-0

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1577222-14-0
Molecular Weight 255.22
Formula C₁₁H₁₃NO₆
SMILES

O=C(OCCN1C(CCC1=O)=O)/C=C/C(OC)=O
Synonyms

ALKS 8700 (Standard); BIIB098 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Angela Wehr, et al. Relative Bioavailability of Monomethyl Fumarate after Administration of ALKS 8700 in Healthy Subjects (P1.403). Neurology. Apr 2018.

[2]. Yousuf MS, et al. Diroximel fumarate acts through Nrf2 to attenuate methylglyoxal-induced nociception in mice and decreases ISR activation in DRG neurons. bioRxiv [Preprint]. 2023 Dec 23:2023.12.22.572877. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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