1603833-56-2
1603833-56-2
Chemical Structure
Amyloid-β-IN-3
- CAS No.: 1603833-56-2
- Formula:C22H21F2N3O2
- Molecular Weight:397.42
InChIKey: KNDVEZJMPNKCSL-OAHLLOKOSA-N
SMILES: FC1=CC(F)=CC(NC(C2=CC3=CC([C@H]4CN(CCC4)C(C)=O)=CC=C3N2)=O)=C1
Biological Activity: Amyloid-β-IN-3 (EX.113) is a selective γ-secretase inhibitor. Amyloid-β-IN-3 inhibits Aβ42 secretion in H4 cells with an EC50 value of 148 nM. Amyloid-β-IN-3 regulates the γ-secretase catalytic activity to decrease Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. Amyloid-β-IN-3 is promising for research of Alzheimer's disease (AD)[1].
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Amyloid-β-IN-3 | 99.50% | Amyloid-β-IN-3 (EX.113) is a selective γ-secretase inhibitor. Amyloid-β-IN-3 inhibits Aβ42 secretion in H4 cells with an EC50 value of 148 nM. Amyloid-β-IN-3 regulates the γ-secretase catalytic activity to decrease Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. Amyloid-β-IN-3 is promising for research of Alzheimer's disease (AD). | ||||||||||||||||||||
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