160963-92-8
Chemical Structure
Wikstrol B
- CAS No.: 160963-92-8
- Formula:C30H22O10
- Molecular Weight:542.49
InChIKey: SRCSHETVEHQXLC-RBISFHTESA-N
SMILES: OC1=CC2=C(C(C(C3=C(O)C=C(O)C4=C3O[C@H](C5=CC=C(O)C=C5)[C@@H](O)C4)=C(C6=CC=C(O)C=C6)O2)=O)C(O)=C1
Biological Activity: Wikstrol B (compound 5) is a biflavonoid microtubule/tubulin inhibitor and HIV-1 inhibitor. Wikstrol B has an IC50 value of 184 μM for microtubule polymerization and an EC50 of 3.02 μM against HIV-1, acting on early events of HIV-1 replication. Wikstrol B exerts antifungal activity by inducing morphological deformation of Pyricularia oryzae hyphae and exerts anti-mitotic activity by inhibiting microtubule polymerization. Wikstrol B can be used in research related to antifungal, antitumor, and anti-AIDS applications. Wikstrol B can be naturally extracted from the roots of Wikstroemia indica[1].
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Wikstrol B | Wikstrol B (compound 5) is a biflavonoid microtubule/tubulin inhibitor and HIV-1 inhibitor. Wikstrol B has an IC50 value of 184 μM for microtubule polymerization and an EC50 of 3.02 μM against HIV-1, acting on early events of HIV-1 replication. Wikstrol B exerts antifungal activity by inducing morphological deformation of Pyricularia oryzae hyphae and exerts anti-mitotic activity by inhibiting microtubule polymerization. Wikstrol B can be used in research related to antifungal, antitumor, and anti-AIDS applications. Wikstrol B can be naturally extracted from the roots of Wikstroemia indica. | |||||||||||||||||||||
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Keywords
