161522-25-4
161522-25-4
Chemical Structure
HSR-609
- CAS No.: 161522-25-4
- Formula:C21H21FN2O3
- Molecular Weight:368.40
IUPAC Name: 3-(4-(8-fluorobenzo[6,7]oxepino[4,3-b]pyridin-11(5H)-ylidene)piperidin-1-yl)propanoic acid
InChIKey: VNMVYPKXIOJAGS-UHFFFAOYSA-N
SMILES: O=C(O)CCN1CC/C(CC1)=C2C3=CC=C(F)C=C3OCC4=CC=CN=C4\2
Biological Activity: HSR-609 is an orally active amphoteric antiallergic agent. HSR-609 has a high affinity for histamine H1-receptor in the guinea pig cerebral cortex. HSR-609 inhibits allergic airway hyperresponsiveness to Acetylcholine. HSR-609 shows poor ability to penetrate into the CNS in mice and guinea pigs[1][2].
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HSR-609 | HSR-609 is an orally active amphoteric antiallergic agent. HSR-609 has a high affinity for histamine H1-receptor in the guinea pig cerebral cortex. HSR-609 inhibits allergic airway hyperresponsiveness to Acetylcholine. HSR-609 shows poor ability to penetrate into the CNS in mice and guinea pigs. | |||||||||||||||||||||
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References
- [1]. M Kakiuchi, et al. Studies on the novel antiallergic agent HSR-609: its penetration into the central nervous system in mice and guinea pigs and its selectivity for the histamine H1-receptor. Jpn J Pharmacol. 1997 Apr;73(4):291-8. [Content Brief]
- [2]. K Musoh, et al. Effect of a novel anti-allergic agent, HSR-609, on antigen-induced airway hyperresponsiveness in mice. Pharmacology. 2000 Aug;61(2):70-7. [Content Brief]
