1616863-09-2
1616863-09-2
Chemical Structure
HDAC-IN-101
- CAS No.: 1616863-09-2
- Formula:C25H19N5O4
- Molecular Weight:453.45
InChIKey: AOOHEBGDZSPKMW-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C=C1)CNC2=CC3=C(C(C4=CC=C(C=C4)[N+]([O-])=O)=N2)NC5=C3C=CC=C5)NO
Biological Activity: HDAC-IN-101 is a HDAC1 inhibitor and nitroreductase/pH-activated fluorescent inducer, with an IC50 of 65 nM against human HDAC1. HDAC-IN-101 blocks cancer cell proliferation by inhibiting HDAC1. HDAC-IN-101 is reduced by overexpressed nitroreductase to generate H6AQ (Ex/Em = 450 nm/500 nm), a product that emits fluorescence under low pH conditions. HDAC-IN-101 is applicable for cancer-related research[1].
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HDAC-IN-101 | HDAC-IN-101 is a HDAC1 inhibitor and nitroreductase/pH-activated fluorescent inducer, with an IC50 of 65 nM against human HDAC1. HDAC-IN-101 blocks cancer cell proliferation by inhibiting HDAC1. HDAC-IN-101 is reduced by overexpressed nitroreductase to generate H6AQ (Ex/Em = 450 nm/500 nm), a product that emits fluorescence under low pH conditions. HDAC-IN-101 is applicable for cancer-related research. | |||||||||||||||||||||
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