1620680-19-4
Chemical Structure
Lp-PLA2-IN-11
- CAS No.: 1620680-19-4
- Formula:C22H20F4N4O3
- Molecular Weight:464.41
IUPAC Name: (R)-8-((3-fluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-1,2-dimethyl-1,2,3,4-tetrahydro-6H-pyrimido[1,6-a]pyrimidin-6-one
InChIKey: WRAGBQQCIJKJRC-CYBMUJFWSA-N
SMILES: O=C1N=C(OCC2=CC=C(OC3=CC=C(C(F)(F)F)N=C3)C(F)=C2)C=C4N(C)[C@H](C)CCN41
Biological Activity: Lp-PLA2-IN-11 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2). Lp-PLA2 previously known as platelet- activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme involved in hydrolysis of lipoprotein lipids or phospholipids. Lp-PLA2-IN-11 has the potential for the research of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease (extracted from patent WO2014114249A1, compound E145)[1].
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Lp-PLA2-IN-11 | Lp-PLA2-IN-11 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2). Lp-PLA2 previously known as platelet- activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme involved in hydrolysis of lipoprotein lipids or phospholipids. Lp-PLA2-IN-11 has the potential for the research of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease (extracted from patent WO2014114249A1, compound E145). | |||||||||||||||||||||
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Keywords
