1620820-12-3
1620820-12-3
Chemical Structure
TL4-12
- CAS No.: 1620820-12-3
- Formula:C25H27F3N6O2
- Molecular Weight:500.52
IUPAC Name: 4-methyl-3-((6-(methylamino)pyrimidin-4-yl)oxy)-N-(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl)benzamide
InChIKey: HXKJJIMUMNPQQY-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C(OC2=NC=NC(NC)=C2)=C1)C)NC3=CC(C(F)(F)F)=CC(N4CCN(CC4)C)=C3
Biological Activity: TL4-12 is a selective MAP4K2/GCK inhibitor, dose-dependently downregulates IKZF1 and BCL-6 and leads to MM cell proliferation inhibition (IC50=37 nM) accompanied by induction of apoptosis. TL4-12 can be used to overcome immunomodulatory agent resistance in multiple myeloma (MM)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TL4-12 | 99.25% | TL4-12 is a selective MAP4K2/GCK inhibitor, dose-dependently downregulates IKZF1 and BCL-6 and leads to MM cell proliferation inhibition (IC50=37 nM) accompanied by induction of apoptosis. TL4-12 can be used to overcome immunomodulatory agent resistance in multiple myeloma (MM). | ||||||||||||||||||||
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