1622212-25-2
1622212-25-2
Chemical Structure
ONO-7579
- CAS. Nr.: 1622212-25-2
- Formula:C24H18ClF3N6O4S
- Molecular Weight:578.95
InChIKey: GYPOVJZOMXEUDO-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(C(F)(F)F)=CC=C1S(=O)(C)=O)NC2=CN=C(OC3=CC=C(C4=CC(Cl)=CN=C4N)C=C3)N=C2
Biological Activity: ONO-7579 is an orally active TRKA inhibitor that suppresses tumor growth by inhibiting the phosphorylation of TRKA. In colorectal cancer cells KM12, its EC50 is 17.6 ng/g (meaning that when each gram of tumor tissue contains 17.6 ng of ONO-7579, the activity of phosphorylated TRKA in the tumor is inhibited by 50%). ONO-7579 can be used in cancer research[1].
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ONO-7579 | ONO-7579 is an orally active TRKA inhibitor that suppresses tumor growth by inhibiting the phosphorylation of TRKA. In colorectal cancer cells KM12, its EC50 is 17.6 ng/g (meaning that when each gram of tumor tissue contains 17.6 ng of ONO-7579, the activity of phosphorylated TRKA in the tumor is inhibited by 50%). ONO-7579 can be used in cancer research. | |||||||||||||||||||||
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