1627576-82-2
1627576-82-2
Chemical Structure
JJC8-088
- CAS No.: 1627576-82-2
- Formula:C28H32F2N2O2S
- Molecular Weight:498.63
InChIKey: MACFTPBZAOCTFN-UHFFFAOYSA-N
SMILES: O=S(C(C1=CC=C(C=C1)F)C2=CC=C(C=C2)F)CCN3CCN(CC3)CC(CC4=CC=CC=C4)O
Biological Activity: JJC8-088, a Modafinil-derived ligand, is a dopamine transporter (DAT) inhibitor with a Ki of 2.53 nM. JJC8-088 dioxalate can be to study psychostimulant use disorders[1][2].
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JJC8-088 | JJC8-088, a Modafinil-derived ligand, is a dopamine transporter (DAT) inhibitor with a Ki of 2.53 nM. JJC8-088 dioxalate can be to study psychostimulant use disorders. | |||||||||||||||||||||
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References
- [1]. Tunstall BJ, et al. Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats. Neuropharmacology. 2018 Mar 15;131:96-103. [Content Brief]
- [2]. Newman AH, et al. Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders. Neuropsychopharmacology. 2019 Jul;44(8):1435-1444. [Content Brief]
Keywords
