1628343-77-0
1628343-77-0
Chemical Structure
ARN726
- CAS No.: 1628343-77-0
- Formula:C14H24N2O3
- Molecular Weight:268.35
IUPAC Name: 4-cyclohexylbutyl (S)-(2-oxoazetidin-3-yl)carbamate
InChIKey: FNLUJRBWJBUJTC-LBPRGKRZSA-N
SMILES: O=C(OCCCCC1CCCCC1)N[C@@H]2C(NC2)=O
Biological Activity: ARN726 is a potent NAAA (N-acylethanolamine acid amidase) inhibitor with an IC50 of 0.073 µM. ARN726 decreases alcohol self-administration in a dose-dependent manner[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ARN726 | 98.10% | ARN726 is a potent NAAA (N-acylethanolamine acid amidase) inhibitor with an IC50 of 0.073 µM. ARN726 decreases alcohol self-administration in a dose-dependent manner. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.72
HY-125384ARN14686 -
Similarity Score 0.61
HY-W008261(S)-2-((tert-Butoxycarbonyl)amino)-3-cyclohexylpropanoic acid -
Similarity Score 0.61
HY-1403505-endo-BCN-pentanoic acid -
Similarity Score 0.59
HY-W583818tert-Butyl (3-(piperidin-4-yl)propyl)carbamate -
Similarity Score 0.59
HY-78609tert-Butyl (trans-4-(2-hydroxyethyl)cyclohexyl)carbamate -
Similarity Score 0.59
HY-157054endo-BCN-L-Lysine -
Similarity Score 0.59
HY-157054A(Rac)-BCN-L-Lysine -
Similarity Score 0.59
HY-W754588exo-BCN-L-Lysine -
Similarity Score 0.59
HY-33021tert-Butyl 4-(4-hydroxybutyl)piperidine-1-carboxylate -
Explore the MedChemAI to find more analogs
References
- [1]. Fotio Y, et al. N-acylethanolamine acid amidase (NAAA) inhibition decreases the motivation for alcohol in Marchigian Sardinian alcohol-preferring rats. Psychopharmacology (Berl). 2021 Jan;238(1):249-258. [Content Brief]
- [2]. Petracca R, et al. Novel activity-based probes for N-acylethanolamine acid amidase. Chem Commun (Camb). 2017 Aug 22;53(86):11810-11813. [Content Brief]
