Novel activity-based probes for N-acylethanolamine acid amidase

  • Chem Commun (Camb). 2017 Aug 22;53(86):11810-11813. doi: 10.1039/c7cc06838g.
Rita Petracca  1 ,  Elisa Romeo ,  Marc P Baggelaar ,  Marta Artola ,  Silvia Pontis ,  Stefano Ponzano ,  Herman S Overkleeft ,  Mario van der Stelt ,  Daniele Piomelli
Affiliations
  • 1. School of Chemistry and Trinity Biomedical Sciences Institute (TBSI), Trinity College Dublin, The University of Dublin, Dublin 2, Ireland.
PMID: 29035406 DOI: 10.1039/c7cc06838g
Abstract

The cysteine hydrolase, N-acylethanolamine acid amidase (NAAA) is a promising target for analgesic and anti-inflammatory drugs. Here, we describe the development of two unprecedented NAAA-reactive activity-based probes as research tools for application in the discovery of new inhibitors and for the in-depth characterization of NAAA in its cellular environment.

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