1685279-23-5
Chemical Structure
XSJ151
- CAS No.: 1685279-23-5
- Formula:C37H31N5O10S
- Molecular Weight:737.73
InChIKey: JGNDYACICADGRZ-QNGWXLTQSA-N
SMILES: COC(C=C1)=CC=C1CC(NCC(O[C@]2(CC)C(OCC3=C2C=C4N(CC5=CC6=CC=CC=C6N=C54)C3=O)=O)=O)=NS(C7=CC=C([N+]([O-])=O)C=C7)(=O)=O
Biological Activity: XSJ151 is a topoisomerase I inhibitor, stabilizing the DNA-Topo I covalent complex and inducing DNA double-strand breaks. XSJ151-induces DNA damage activates the p53-p21 signaling pathway, specifically regulating the expression of cyclins, leading to G2/M phase cell cycle arrest and disrupting the dynamic homeostasis of Bcl-2 family proteins, thereby triggering apoptosis in gastric cancer cells. XSJ151 can be used for the study of gastric cancer[1].
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XSJ151 | XSJ151 is a topoisomerase I inhibitor, stabilizing the DNA-Topo I covalent complex and inducing DNA double-strand breaks. XSJ151-induces DNA damage activates the p53-p21 signaling pathway, specifically regulating the expression of cyclins, leading to G2/M phase cell cycle arrest and disrupting the dynamic homeostasis of Bcl-2 family proteins, thereby triggering apoptosis in gastric cancer cells. XSJ151 can be used for the study of gastric cancer. | |||||||||||||||||||||
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Keywords
