168835-59-4
168835-59-4
Chemical Structure
Desmethyl Sibutramine
Synonym(s): N-Desmethylsibutramine
- CAS No.: 168835-59-4
- Formula:C16H24ClN
- Molecular Weight:265.82
IUPAC Name: 1-(1-(4-chlorophenyl)cyclobutyl)-N,3-dimethylbutan-1-amine
InChIKey: PLXKZKLXYHLWHR-UHFFFAOYSA-N
SMILES: CC(C)CC(C1(C2=CC=C(Cl)C=C2)CCC1)NC
Biological Activity: Desmethyl Sibutramine, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine can be used in the research of obesity and appetite suppressant[1][2][3][4].
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Desmethyl Sibutramine | 99.45% | Desmethyl Sibutramine, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine can be used in the research of obesity and appetite suppressant. | ||||||||||||||||||||
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References
- [1]. Talbot PS, et, al. Brain serotonin transporter occupancy by oral sibutramine dosed to steady state: a PET study using (11)C-DASB in healthy humans. Neuropsychopharmacology. 2010 Feb;35(3):741-51. [Content Brief]
- [2]. Luscombe GP, et, al. The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. Neuropharmacology. 1989 Feb;28(2):129-34. [Content Brief]
- [3]. Wang J, et, al. Analysis of six synthetic adulterants in herbal weight-reducing dietary supplements by LC electrospray ionization-MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Jul;25(7):822-30. [Content Brief]
- [4]. Ponnuru VS, et, al. Quantification of sibutramine and its two metabolites in human plasma by LC-ESI-MS/MS and its application in a bioequivalence study. J Pharm Anal. 2012 Aug;2(4):249-257. [Content Brief]
Keywords
