169521-68-0
169521-68-0
Chemical Structure
17-DMAP-GA
- CAS No.: 169521-68-0
- Formula:C33H50N4O8
- Molecular Weight:630.77
IUPAC Name: (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-((3-(dimethylamino)propyl)amino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
InChIKey: UNPSMUMJWYZQHC-CYVBNFEDSA-N
SMILES: CN(C)CCCNC(C(C=C1NC(/C(C)=C/C=C\[C@@H]2OC)=O)=O)=C(C[C@H](C[C@@H]([C@@H]([C@H](/C=C([C@@H]2OC(N)=O)\C)C)O)OC)C)C1=O
Biological Activity: 17-DMAP-GA, a Geldanamycin (HY-15230) analogue, is an inhibitor of HSP90. 17-DMAP-GA causes cell cycle abnormalities[1][2].
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17-DMAP-GA | 17-DMAP-GA, a Geldanamycin (HY-15230) analogue, is an inhibitor of HSP90. 17-DMAP-GA causes cell cycle abnormalities. | |||||||||||||||||||||
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References
- [1]. Jurczyszyn A, et al. Geldanamycin and Its Derivatives Inhibit the Growth of Myeloma Cells and Reduce the Expression of the MET Receptor. J Cancer. 2014;5(6):480-490. Published 2014 May 31. [Content Brief]
- [2]. Tian ZQ, et al. Synthesis and biological activities of novel 17-aminogeldanamycin derivatives. Bioorg Med Chem. 2004;12(20):5317-5329. [Content Brief]
