170508-05-1
170508-05-1
Chemical Structure
Lanepitant dihydrochloride
Synonym(s): LY303870 dihydrochloride
- CAS No.: 170508-05-1
- Formula:C33H47Cl2N5O3
- Molecular Weight:632.66
IUPAC Name: (R)-N-(1-(1H-indol-3-yl)-3-(N-(2-methoxybenzyl)acetamido)propan-2-yl)-2-([1,4'-bipiperidin]-1'-yl)acetamide dihydrochloride
InChIKey: WURFRVBOVGQPHZ-QDSLRZTOSA-N
SMILES: COC(C=CC=C1)=C1CN(C(C)=O)C[C@H](NC(CN2CCC(N3CCCCC3)CC2)=O)CC4=CNC5=C4C=CC=C5.Cl.Cl
Biological Activity: Lanepitant dihydrochloride (LY303870 dihydrochloride) is a non-peptide neurokinin-1 receptor antagonist. Lanepitant dihydrochloride has analgesic and anti-inflammatory activities[1][2].
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Lanepitant dihydrochloride | Lanepitant dihydrochloride (LY303870 dihydrochloride) is a non-peptide neurokinin-1 receptor antagonist. Lanepitant dihydrochloride has analgesic and anti-inflammatory activities. | |||||||||||||||||||||
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References
- [1]. Goldstein DJ, et al. Lanepitant, an NK-1 antagonist, in migraine prevention. Cephalalgia. 2001 Mar;21(2):102-6. [Content Brief]
- [2]. Goldstein DJ, et al. Study of the analgesic effect of lanepitant in patients with osteoarthritis pain. Clin Pharmacol Ther. 2000 Apr;67(4):419-26. [Content Brief]
