1708103-76-7
1708103-76-7
Chemical Structure
ARTD10/PARP10-IN-1
- CAS No.: 1708103-76-7
- Formula:C12H12N2O4
- Molecular Weight:248.23
IUPAC Name: methyl (Z)-4-((3-carbamoylphenyl)amino)-4-oxobut-2-enoate
InChIKey: KXULAXICDCSUDZ-WAYWQWQTSA-N
SMILES: COC(/C=C\C(NC1=CC(C(N)=O)=CC=C1)=O)=O
Biological Activity: ARTD10/PARP10-IN-1 (compound 23) is a potent and non-selective PARP inhibitor, targeting to mono-ADP-ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 (ARTD1/PARP1) with IC50s of 1.7 μM, 1.6 μM, 0.8 μM, and 4.4 μM, respectively[1].
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ARTD10/PARP10-IN-1 | ARTD10/PARP10-IN-1 (compound 23) is a potent and non-selective PARP inhibitor, targeting to mono-ADP-ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 (ARTD1/PARP1) with IC50s of 1.7 μM, 1.6 μM, 0.8 μM, and 4.4 μM, respectively. | |||||||||||||||||||||
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