172903-00-3
172903-00-3
Chemical Structure
Triplatin tetranitrate
- CAS No.: 172903-00-3
- Formula:C12H40Cl2N14O12Pt3
- Molecular Weight:1228.69
InChIKey: XVQSCSHQAZUHOA-UHFFFAOYSA-L
SMILES: N[Pt+2](NCCCCCCN[Pt+2](N)(N)[Cl-])(N)NCCCCCCN[Pt+2](N)(N)[Cl-].O=N([O-])=O.O=N([O-])=O.O=N([O-])=O.O=N([O-])=O
Biological Activity: Triplatin tetranitrate is a novel trinuclear platinum complex. Triplatin tetranitrate blocks G2/M phase. Triplatin tetranitrate can covalently bind to the DNA bases. Triplatin tetranitrate exhibits significant antitumor effects against neuroblastoma[1][2].
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Triplatin tetranitrate | Triplatin tetranitrate is a novel trinuclear platinum complex. Triplatin tetranitrate blocks G2/M phase. Triplatin tetranitrate can covalently bind to the DNA bases. Triplatin tetranitrate exhibits significant antitumor effects against neuroblastoma. | |||||||||||||||||||||
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References
- [1]. Riccardi A, et al. In vitro and in vivo antitumor activity of the novel trinuclear platinum complex BBR 3464 in neuroblastoma. Cancer Chemother Pharmacol. 2001 Jun;47(6):498-504. [Content Brief]
- [2]. Banerjee T, et al. Compacting effect of BBR3464, a new-generation trisplatinum anticancer agent, on DNA. Biochimie. 2010 Jul;92(7):846-51. [Content Brief]
Keywords
