173653-47-9
173653-47-9
Chemical Structure
Monomethyl auristatin E intermediate-15
- CAS No.: 173653-47-9
- Formula:C20H29NO5
- Molecular Weight:363.45
IUPAC Name: (S)-tert-butyl 2-((1R,2S)-3-(benzyloxy)-1-hydroxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate
InChIKey: IJTMTCBOXNAACY-BHYGNILZSA-N
SMILES: O[C@H]([C@H](C)C(OCC1=CC=CC=C1)=O)[C@H]2N(C(OC(C)(C)C)=O)CCC2
Biological Activity: Monomethyl auristatin E intermediate-15 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
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Monomethyl auristatin E intermediate-15 | 95.04% | Monomethyl auristatin E intermediate-15 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs). | ||||||||||||||||||||
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References
