174627-50-0
174627-50-0
Chemical Structure
L759633
- CAS No.: 174627-50-0
- Formula:C26H40O2
- Molecular Weight:384.59
IUPAC Name: (6aR,10aR)-1-methoxy-6,6,9-trimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromene
InChIKey: SUFMHSFGODDLKI-NHCUHLMSSA-N
SMILES: COC1=C2[C@@]3([H])[C@](CC=C(C)C3)([H])C(C)(C)OC2=CC(C(C)(C)CCCCCC)=C1
Biological Activity: L759633 is a potent and selective agonist of cannabinoid receptor (CB2) receptor, with Kis of 6.4 nM and 1043 nM for CB2 and CB1 receptors, respectively. L759633 can inhibit Forskolin-stimulated cAMP production[1][2].
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L759633 | 99.9% | L759633 is a potent and selective agonist of cannabinoid receptor (CB2) receptor, with Kis of 6.4 nM and 1043 nM for CB2 and CB1 receptors, respectively. L759633 can inhibit Forskolin-stimulated cAMP production. | ||||||||||||||||||||
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References
- [1]. Ross RA, et, al. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. Br J Pharmacol. 1999 Feb;126(3):665-72. [Content Brief]
- [2]. Dhopeshwarkar A, et, al. Functional Selectivity of CB2 Cannabinoid Receptor Ligands at a Canonical and Noncanonical Pathway. J Pharmacol Exp Ther. 2016 Aug;358(2):342-51. [Content Brief]
Keywords
