174664-65-4
Chemical Structure
m-Carboxycinnamic acid bishydroxamide
Synonym(s): CBHA
- CAS No.: 174664-65-4
- Formula:C10H10N2O4
- Molecular Weight:222.20
IUPAC Name: (E)-N-hydroxy-3-(3-(hydroxyamino)-3-oxoprop-1-en-1-yl)benzamide
InChIKey: OYKBQNOPCSXWBL-SNAWJCMRSA-N
SMILES: O=C(C1=CC=CC(/C=C/C(NO)=O)=C1)NO
Biological Activity: m-Carboxycinnamic acid bishydroxamide (CBHA) is a histone deacetylase inhibitor. m-Carboxycinnamic acid bishydroxamide modulates histone acetylation sites, alters DNA methylation and epigenetic status, increases global histone acetylation, alleviates transcription repression, and facilitates chromatin remodelling. m-Carboxycinnamic acid bishydroxamide can be used for the research of cloned embryo development and epigenetic regulation[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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m-Carboxycinnamic acid bishydroxamide | 98.0% | m-Carboxycinnamic acid bishydroxamide (CBHA) is a histone deacetylase inhibitor. m-Carboxycinnamic acid bishydroxamide modulates histone acetylation sites, alters DNA methylation and epigenetic status, increases global histone acetylation, alleviates transcription repression, and facilitates chromatin remodelling. m-Carboxycinnamic acid bishydroxamide can be used for the research of cloned embryo development and epigenetic regulation. | ||||||||||||||||||||
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References
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[1]. Ling S, et al. Derivation of androgenetic embryonic stem cells from
m-carboxycinnamic acid bishydroxamide (CBHA) treated
androgenetic embryos. Chin. Sci. Bull. 2013 June 11;58:2862-2868. - [2]. Agrawal H, et al. m-carboxycinnamic acid bishydroxamide improves developmental competence, reduces apoptosis and alters epigenetic status and gene expression pattern in cloned buffalo (Bubalus bubalis) embryos. Reprod Domest Anim. 2018;53(4):986-996. [Content Brief]
- [3]. Dai X, et al. Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide, a histone deacetylase inhibitor. J Biol Chem. 2010 Oct 1;285(40):31002-10. [Content Brief]
