1781941-93-2
1781941-93-2
Chemical Structure
ROS 234 dioxalate
- CAS No.: 1781941-93-2
- Formula:C17H19N5O8
- Molecular Weight:421.36
IUPAC Name: N-(3-(1H-imidazol-5-yl)propyl)-1H-benzo[d]imidazol-2-amine dioxalate
InChIKey: JKTBCMILCFDKEJ-UHFFFAOYSA-N
SMILES: O=C(O)C(O)=O.O=C(O)C(O)=O.C1(NCCCC2=CN=CN2)=NC3=CC=CC=C3N1
Biological Activity: ROS 234 dioxalate is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 dioxalate diaplays poor central access[1][2].
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ROS 234 dioxalate | ROS 234 dioxalate is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 dioxalate diaplays poor central access. | |||||||||||||||||||||
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References
- [1]. Ballabeni V, et al. CNS access of selected H3-antagonists: ex vivo binding study in rats. Inflamm Res. 2002 Apr;51 Suppl 1:S55-6. [Content Brief]
- [2]. Mor M, et al. Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists. Bioorg Med Chem. 2004 Feb 15;12(4):663-74. [Content Brief]
