179169-88-1
179169-88-1
Chemical Structure
Homo-AMPA
- CAS No.: 179169-88-1
- Formula:C8H12N2O4
- Molecular Weight:200.19
InChIKey: NZDIZJGEDFARSV-UHFFFAOYSA-N
SMILES: O=C1NOC(C)=C1CCC(C(O)=O)N
Biological Activity: Homo-AMPA is a stereospecific mGluR6 agonist (EC50 = 58 μM) and a weak NMDA (HY-17551) receptor antagonist (IC50 = 131 μM), exerting anxiolytic-like effects and modulating pain-responsive neuronal activity through selective activation of mGluR6. Homo-AMPA can serve as a standard agonist for the pharmacological characterization of mGluR6 in related studies[1][2][3][4][5][6].
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Homo-AMPA | Homo-AMPA is a stereospecific mGluR6 agonist (EC50 = 58 μM) and a weak NMDA (HY-17551) receptor antagonist (IC50 = 131 μM), exerting anxiolytic-like effects and modulating pain-responsive neuronal activity through selective activation of mGluR6. Homo-AMPA can serve as a standard agonist for the pharmacological characterization of mGluR6 in related studies. | |||||||||||||||||||||
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References
- [1]. Palazzo E, et al. The Cold Case of Metabotropic Glutamate Receptor 6: Unjust Detention in the Retina?. Current neuropharmacology. 2020;18(2):120-125.
- [2]. P Krogsgaard-Larsen, et al. Design of excitatory amino acid receptor agonists, partial agonists and antagonists: ibotenic acid as a key lead structure, European Journal of Medicinal Chemistry, Volume 31, Issues 7–8, 1996, Pages 515-537, ISSN 0223-5234.
- [3]. Selective Agonists at Group II Metabotropic Glutamate Receptors: Synthesis, Stereochemistry, and Molecular Pharmacology of (S)- and (R)-2-Amino-4-(4-hydroxy[1 …
- [4]. Greenwood JR, et al. 3-hydroxypyridazine 1-oxides as carboxylate bioisosteres: a new series of subtype-selective AMPA receptor agonists. Neuropharmacology. 2006 Jul;51(1):52-9.
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[5]. U Madsen, et al. Design, synthesis and pharmacology of model compounds for indirect elucidation of the topography of AMPA receptor sites, European Journal of Medicinal Chemistry,
Volume 28, Issue 10, 1993, Pages 791-800, ISSN 0223-5234. - [6]. Xi ZX, et al. Inhibition of non-vesicular glutamate release by group III metabotropic glutamate receptors in the nucleus accumbens. Journal of neurochemistry. 2003 Dec;87(5):1204-12.
