1792977-97-9
Chemical Structure
DOTA-MLN6907
- CAS No.: 1792977-97-9
- Formula:C85H123N21O28S7
- Molecular Weight:2111.47
InChIKey: LJVNGQOZCMLZJQ-KLYBNSOLSA-N
SMILES: O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)[C@@H](CC2=CC=C(NC(NCCCCCC(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@@H](C)C(NC3)=O)=O)NC4=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H]5CSSC[C@@H](C(N[C@@H](CC6=CC=C(C=C6)O)C(O)=O)=O)NC3=O)=O)=O)=O)=O)CSSC[C@H](C(N[C@@H](CC(N)=O)C(N7[C@@H](CCC7)C(N[C@H]4C)=O)=O)=O)NC5=O)=O)=S)C=C2)CN(CC(O)=O)CC1
Biological Activity: DOTA-MLN6907 is a guanylate cyclase C (GCC) binding agent. DOTA-MLN6907 competitively binds GCC receptors in vitro with an IC50 of approximately 4.6 nM. DOTA-MLN6907, after labeling with Ga-68, can specifically bind to GCC-expressing cancer cells for PET imaging. DOTA-MLN6907 can be used for PET imaging studies of GCC-expressing tumors such as colorectal cancer and for stratified assessment of GCC expression levels[1].
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DOTA-MLN6907 | DOTA-MLN6907 is a guanylate cyclase C (GCC) binding agent. DOTA-MLN6907 competitively binds GCC receptors in vitro with an IC50 of approximately 4.6 nM. DOTA-MLN6907, after labeling with Ga-68, can specifically bind to GCC-expressing cancer cells for PET imaging. DOTA-MLN6907 can be used for PET imaging studies of GCC-expressing tumors such as colorectal cancer and for stratified assessment of GCC expression levels. | |||||||||||||||||||||
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