DOTA-MLN6907
DOTA-MLN6907 is a guanylate cyclase C (GCC) binding agent. DOTA-MLN6907 competitively binds GCC receptors in vitro with an IC50 of approximately 4.6 nM. DOTA-MLN6907, after labeling with Ga-68, can specifically bind to GCC-expressing cancer cells for PET imaging. DOTA-MLN6907 can be used for PET imaging studies of GCC-expressing tumors such as colorectal cancer and for stratified assessment of GCC expression levels.
For research use only. We do not sell to patients.
- CAS No.: 1792977-97-9
- Formula: C85H123N21O28S7
- Molecular Weight:2111.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
DOTA-MLN6907 (MLN6907 DSP) (0.5 μM-8.5 μM) inhibits the binding of [111In] MLN6907 to GCC in HEK-293 GCC Clone 2 cells via a competitive binding assay, with an IC50 of 4.59 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1792977-97-9
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Molecular Weight 2111.47
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Formula C85H123N21O28S7
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SMILES
O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)[C@@H](CC2=CC=C(NC(NCCCCCC(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@@H](C)C(NC3)=O)=O)NC4=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H]5CSSC[C@@H](C(N[C@@H](CC6=CC=C(C=C6)O)C(O)=O)=O)NC3=O)=O)=O)=O)=O)CSSC[C@H](C(N[C@@H](CC(N)=O)C(N7[C@@H](CCC7)C(N[C@H]4C)=O)=O)=O)NC5=O)=O)=S)C=C2)CN(CC(O)=O)CC1
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Sequence
{(S)-p-SCN-Bn-DOTA}-Ahx-Cys-Cys-Glu-Leu-Cys-Cys-Asn-Pro-Ala-Cys-Ala-Gly-Cys-Tyr (disulfide bridge:Cys1-Cys6, Cys2-Cys10, Cys5-Cys13)
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Sequence Shortening
{(S)-p-SCN-Bn-DOTA}-Ahx-CCELCCNPACAGCY (disulfide bridge:Cys1-Cys6, Cys2-Cys10, Cys5-Cys13)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DOTA-MLN6907 Related Classifications
HY-P12379 Related Classifications
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