DOTA-MLN6907
DOTA-MLN6907 is a guanylate cyclase C (GCC) binding agent. DOTA-MLN6907 competitively binds GCC receptors in vitro with an IC50 of approximately 4.6 nM. DOTA-MLN6907, after labeling with Ga-68, can specifically bind to GCC-expressing cancer cells for PET imaging. DOTA-MLN6907 can be used for PET imaging studies of GCC-expressing tumors such as colorectal cancer and for stratified assessment of GCC expression levels.
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- CAS. Nr.: 1792977-97-9
- Formel: C85H123N21O28S7
- Molecular Weight:2111.47
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1792977-97-9
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Molecular Weight 2111.47
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Formel C85H123N21O28S7
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SMILES
O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)[C@@H](CC2=CC=C(NC(NCCCCCC(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@@H](C)C(NC3)=O)=O)NC4=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H]5CSSC[C@@H](C(N[C@@H](CC6=CC=C(C=C6)O)C(O)=O)=O)NC3=O)=O)=O)=O)=O)CSSC[C@H](C(N[C@@H](CC(N)=O)C(N7[C@@H](CCC7)C(N[C@H]4C)=O)=O)=O)NC5=O)=O)=S)C=C2)CN(CC(O)=O)CC1
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Sequence
{(S)-p-SCN-Bn-DOTA}-Ahx-Cys-Cys-Glu-Leu-Cys-Cys-Asn-Pro-Ala-Cys-Ala-Gly-Cys-Tyr (disulfide bridge:Cys1-Cys6, Cys2-Cys10, Cys5-Cys13)
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Sequence Shortening
{(S)-p-SCN-Bn-DOTA}-Ahx-CCELCCNPACAGCY (disulfide bridge:Cys1-Cys6, Cys2-Cys10, Cys5-Cys13)
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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