179598-53-9
179598-53-9
Chemical Structure
PD159790
- CAS No.: 179598-53-9
- Formula:C16H18F3IN4
- Molecular Weight:450.24
IUPAC Name: N-(1-ethylpiperidin-3-yl)-6-iodo-2-(trifluoromethyl)quinazolin-4-amine
InChIKey: IRWWFCJIOHCTMV-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=NC(NC2CN(CCC2)CC)=C3C=C(C=CC3=N1)I
Biological Activity: PD159790 is a selective endothelin-converting enzyme-1 (ECE-1) inhibitor, with an EC50 of 28.1 μM[1][2][3].
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PD159790 | PD159790 is a selective endothelin-converting enzyme-1 (ECE-1) inhibitor, with an EC50 of 28.1 μM. | |||||||||||||||||||||
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References
- [1]. Janet Maguire, et al. Alternative pathway to endothelin-converting enzyme for the synthesis of endothelin in human blood vessels. J Cardiovasc Pharmacol. 2004 Nov:44 Suppl 1:S27-9. [Content Brief]
- [2]. F D Russell, et al. Evidence for intracellular endothelin-converting enzyme-2 expression in cultured human vascular endothelial cells. Circ Res. 1999 Apr 30;84(8):891-6. [Content Brief]
- [3]. K Ahn, et al. Novel selective quinazoline inhibitors of endothelin converting enzyme-1. Biochem Biophys Res Commun. 1998 Feb 4;243(1):184-90. [Content Brief]
Keywords
