1801749-44-9
Chemical Structure
Ceclazepide
Synonym(s): TR2-A
- CAS No.: 1801749-44-9
- Formula:C30H32N6O5
- Molecular Weight:556.61
IUPAC Name: (R)-2,2-dimethyl-4-(3-(3-(3-(methylamino)phenyl)ureido)-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)-3-oxobutyl acetate
InChIKey: GPEYTRIZYSZRRK-MHZLTWQESA-N
SMILES: CC(OCC(C)(C)C(CN1C2=CC=CC=C2C(C3=CC=CC=N3)=N[C@H](C1=O)NC(NC4=CC(NC)=CC=C4)=O)=O)=O
Biological Activity: Ceclazepide (TR2-A), a CCK2R antagonist, is an orally active Mycobacterium abscessus inhibitor. Ceclazepide inhibits acid secretion in rats. Ceclazepide effectively suppresses the growth of M. abscessus wild-type strain and multiple subspecies. Ceclazepide inhibits M. abscessus growth within macrophages without causing harm[1][2].
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Ceclazepide | Ceclazepide (TR2-A), a CCK2R antagonist, is an orally active Mycobacterium abscessus inhibitor. Ceclazepide inhibits acid secretion in rats. Ceclazepide effectively suppresses the growth of M. abscessus wild-type strain and multiple subspecies. Ceclazepide inhibits M. abscessus growth within macrophages without causing harm. | |||||||||||||||||||||
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References
- [1]. K.L. Therese, et al. Ceclazepide as novel Mycobacterium abscessus inhibitor. bioRxiv. April 03, 2024.
- [2]. Chen D, et al. Neuroendocrine mechanism of gastric acid secretion: Historical perspectives and recent developments in physiology and pharmacology. J Neuroendocrinol. 2023 Nov;35(11):e13305. [Content Brief]
