1807775-88-7
1807775-88-7
Chemical Structure
Caf1-IN-1
- CAS No.: 1807775-88-7
- Formula:C18H23N5O3
- Molecular Weight:357.41
InChIKey: ITTTVNWVCMFMMP-UHFFFAOYSA-N
SMILES: O=C1C2=C(N(CCCN(C)C)C(N1O)=O)N=CN2CCC3=CC=CC=C3
Biological Activity: Caf1-IN-1 (compound 8j) is a potent ribonuclease Caf1 inhibitor with an IC50 of 0.59 μM against hCaf1. Caf1-IN-1 blocks deadenylation by targeting the bivalent metal-dependent poly (A)-selective exoribonuclease activity. Caf1-IN-1 is also a weak inhibitor of the deadenylase PARN, with an IC50 of 23.9 μM. Caf1-IN-1 can be used in research on bone formation, obesity, and leukemia[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Caf1-IN-1 | 98.92% | Caf1-IN-1 (compound 8j) is a potent ribonuclease Caf1 inhibitor with an IC50 of 0.59 μM against hCaf1. Caf1-IN-1 blocks deadenylation by targeting the bivalent metal-dependent poly (A)-selective exoribonuclease activity. Caf1-IN-1 is also a weak inhibitor of the deadenylase PARN, with an IC50 of 23.9 μM. Caf1-IN-1 can be used in research on bone formation, obesity, and leukemia. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.54
HY-135501Bamifylline -
Similarity Score 0.53
HY-121453Bamifylline hydrochloride -
Similarity Score 0.52
HY-130786Denbufylline -
Similarity Score 0.52
HY-182518MDL-102234 -
Similarity Score 0.52
HY-169520VEGFR/PDGFR-IN-1 -
Similarity Score 0.52
HY-U00142A-802715 -
Similarity Score 0.51
HY-U00018(±)-Tazifylline -
Similarity Score 0.51
HY-135490Reproterol -
Similarity Score 0.51
HY-107203Propentofylline -
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