182322-62-9
182322-62-9
Chemical Structure
Genistein 7-sulfate
- CAS No.: 182322-62-9
- Formula:C15H10O8S
- Molecular Weight:350.30
IUPAC Name: 5-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl hydrogen sulfate
InChIKey: DKEIWIJUHWVGRC-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC=C(O)C=C2)=COC3=CC(OS(=O)(O)=O)=CC(O)=C13
Biological Activity: Genistein 7-sulfate is a metabolite of Genistein (HY-14596). Genistein 7-sulfate weakly induces PON1 transactivation. Genistein 7-sulfate induces ALP activity. Genistein 7-sulfate can be used in research on breast cancer and liver cancer[1][2][3][4][5][6].
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Genistein 7-sulfate | Genistein 7-sulfate is a metabolite of Genistein (HY-14596). Genistein 7-sulfate weakly induces PON1 transactivation. Genistein 7-sulfate induces ALP activity. Genistein 7-sulfate can be used in research on breast cancer and liver cancer. | |||||||||||||||||||||
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References
- [1]. Peterson TG, et al. The role of metabolism in mammary epithelial cell growth inhibition by the isoflavones genistein and biochanin A. Carcinogenesis. 1996 Sep;17(9):1861-9.
- [2]. Peterson TG, et al. Metabolism of the isoflavones genistein and biochanin A in human breast cancer cell lines. The American journal of clinical nutrition. 1998 Dec 1;68(6):1505S-11S.
- [3]. Grgic D, et al. In vitro evidence for estrogen receptor activity of selected phase II isoflavone metabolites. Archives of toxicology. 2026 Aug;100(8):3567-3582.
- [4]. Konstantinou EK, et al. Molecular Pathways of Genistein Activity in Breast Cancer Cells. International journal of molecular sciences. 2024 May 20;25(10):5556.
- [5]. Schrader C, et al. Genistein as a potential inducer of the anti-atherogenic enzyme paraoxonase-1: studies in cultured hepatocytes in vitro and in rat liver in vivo. Journal of cellular and molecular medicine. 2012 Oct;16(10):2331-41.
- [6]. Grgic D, et al. Modulatory effects of isoflavones and zearalenone metabolites on deoxynivalenol induced gut barrier toxicity in vitro. Mycotoxin research. 2026 Mar 30;42(2):36.
