1826026-00-9
Chemical Structure
ML404
- CAS No.: 1826026-00-9
- Formula:C17H13ClN2O3
- Molecular Weight:328.75
IUPAC Name: N-(5-chloro-2-methylphenyl)-5-(3-hydroxyphenyl)isoxazole-3-carboxamide
InChIKey: IGFGYIMMNXHPFY-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(Cl)=CC=C1C)C2=NOC(C3=CC=CC(O)=C3)=C2
Biological Activity: ML404 (Compound 38) is an inhibitor of the mitochondrial permeability transition pore (mtPTP), which can suppress mitochondrial swelling (EC50=4.9 nM) and only disrupts mitochondrial coupling (an adverse effect) at concentrations > 100 μM. ML404 can be utilized in research related to multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), muscular dystrophies (MD), myocardial infarction, and stroke[1].
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ML404 | ML404 (Compound 38) is an inhibitor of the mitochondrial permeability transition pore (mtPTP), which can suppress mitochondrial swelling (EC50=4.9 nM) and only disrupts mitochondrial coupling (an adverse effect) at concentrations > 100 μM. ML404 can be utilized in research related to multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), muscular dystrophies (MD), myocardial infarction, and stroke. | |||||||||||||||||||||
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Keywords
