183320-29-8
183320-29-8
Chemical Structure
OSI-413 free base
Synonym(s): CP 373413
- CAS No.: 183320-29-8
- Formula:C21H21N3O4
- Molecular Weight:379.41
IUPAC Name: 2-((4-((3-ethynylphenyl)amino)-6-(2-methoxyethoxy)quinazolin-7-yl)oxy)ethanol
InChIKey: MTLKTHNRZJKPRP-UHFFFAOYSA-N
SMILES: OCCOC1=C(OCCOC)C=C2C(N=CN=C2NC3=CC(C#C)=CC=C3)=C1
Biological Activity: OSI-413 (free base) (CP 373413) is a major metabolite of Erlotinib (HY-50896). Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1][2].
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OSI-413 free base | OSI-413 (free base) (CP 373413) is a major metabolite of Erlotinib (HY-50896). Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR. | |||||||||||||||||||||
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References
- [1]. Takuya Ishida, et al. Simultaneous determination of erlotinib and its isomeric major metabolites in human plasma using isocratic liquid chromatography-tandem mass spectrometry and its clinical application. Biomed Chromatogr [Content Brief]
- [2]. Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997, 57(21), 4838-4848. [Content Brief]
Keywords
