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製品番号: HY-15661A

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OSI-413 free base

(別名: CP 373413)

OSI-413 (free base) (CP 373413) is a major metabolite of Erlotinib (HY-50896). Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC₅₀ of 2 nM for human EGFR.

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CAS 番号: 183320-29-8
分子式: C₂₁H₂₁N₃O₄
分子量:379.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

OSI-413 free base 構造式

CAS 番号: 183320-29-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

OSI-413 (free base) (CP 373413) is a major metabolite of Erlotinib (HY-50896). Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC₅₀ of 2 nM for human EGFR^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	1.27 μM Compound: GJT-0383	Antiproliferative activity against human A431 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human A431 cells after 72 hrs by CCK-8 assay	[PMID: 26487917]
HCC827	IC₅₀	0.014 μM Compound: GJT-0383	Antiproliferative activity against human HCC827 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human HCC827 cells after 72 hrs by CCK-8 assay	[PMID: 26487917]

化学情報

CAS 番号 183320-29-8
分子量 379.41
分子式 C₂₁H₂₁N₃O₄
SMILES

OCCOC1=C(OCCOC)C=C2C(N=CN=C2NC3=CC(C#C)=CC=C3)=C1
別名

CP 373413
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Takuya Ishida, et al. Simultaneous determination of erlotinib and its isomeric major metabolites in human plasma using isocratic liquid chromatography-tandem mass spectrometry and its clinical application. Biomed Chromatogr [Content Brief]

[2]. Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997, 57(21), 4838-4848. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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