OSI-413 free base
OSI-413 (free base) (CP 373413) is a major metabolite of Erlotinib (HY-50896). Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR.
For research use only. We do not sell to patients.
- CAS No.: 183320-29-8
- Formula: C21H21N3O4
- Molecular Weight:379.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
1.27 μM
Compound: GJT-0383
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Antiproliferative activity against human A431 cells after 72 hrs by CCK-8 assay
Antiproliferative activity against human A431 cells after 72 hrs by CCK-8 assay
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[PMID: 26487917] |
| HCC827 | IC50 |
0.014 μM
Compound: GJT-0383
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Antiproliferative activity against human HCC827 cells after 72 hrs by CCK-8 assay
Antiproliferative activity against human HCC827 cells after 72 hrs by CCK-8 assay
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[PMID: 26487917] |
Chemical Information
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CAS No. 183320-29-8
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Molecular Weight 379.41
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Formula C21H21N3O4
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SMILES
OCCOC1=C(OCCOC)C=C2C(N=CN=C2NC3=CC(C#C)=CC=C3)=C1
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Synonyms
CP 373413
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Takuya Ishida, et al. Simultaneous determination of erlotinib and its isomeric major metabolites in human plasma using isocratic liquid chromatography-tandem mass spectrometry and its clinical application. Biomed Chromatogr [Content Brief]
[2]. Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997, 57(21), 4838-4848. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OSI-413 free base Related Classifications
HY-15661A Related Classifications
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