183387-50-0
Chemical Structure
Apoptone
Synonym(s): HE3235
- CAS No.: 183387-50-0
- Formula:C21H32O2
- Molecular Weight:316.48
IUPAC Name: (3R,5S,8R,9S,10S,13S,14S,17R)-17-ethynyl-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol
InChIKey: CKAXZOYFIHQCBN-JRRMKBMNSA-N
SMILES: O[C@@]1(C#C)CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
Biological Activity: Apoptone (HE3235) is an orally active 3β-androstanediol analog. Apoptone reduces the expression of androgen receptor (Androgen receptor) and decreases intratumoral androgen levels. Apoptone exhibits anticancer activity against castration-resistant prostate cancer[1][2].
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Apoptone | Apoptone (HE3235) is an orally active 3β-androstanediol analog. Apoptone reduces the expression of androgen receptor (Androgen receptor) and decreases intratumoral androgen levels. Apoptone exhibits anticancer activity against castration-resistant prostate cancer. | |||||||||||||||||||||
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- [1]. Ahlem C, et al. 17α-alkynyl 3α, 17β-androstanediol non-clinical and clinical pharmacology, pharmacokinetics and metabolism. Invest New Drugs. 2012 Feb;30(1):59-78. [Content Brief]
- [2]. Koreckij TD, et al. HE3235 inhibits growth of castration-resistant prostate cancer. Neoplasia. 2009 Nov;11(11):1216-25. [Content Brief]
Keywords
