186379-49-7
186379-49-7
Chemical Structure
MT-21
- CAS No.: 186379-49-7
- Formula:C16H27NO3
- Molecular Weight:281.39
IUPAC Name: 3-acetyl-5-hydroxy-4,5-dimethyl-1-octyl-1,5-dihydro-2H-pyrrol-2-one
InChIKey: IWFCPVZRZLDTPI-UHFFFAOYSA-N
SMILES: O=C1N(CCCCCCCC)C(C)(O)C(C)=C1C(C)=O
Biological Activity: MT-21 is an Apoptosis inducer and adenine nucleotide translocase inhibitor. MT-21 induces Apoptosis by activating JNK via the Krs/MST protein. MT-21 activates caspase-3 via caspase-9. MT-21 induces the release of cytochrome c. MT-21 can be used in the research of tumors[1][2].
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MT-21 | MT-21 is an Apoptosis inducer and adenine nucleotide translocase inhibitor. MT-21 induces Apoptosis by activating JNK via the Krs/MST protein. MT-21 activates caspase-3 via caspase-9. MT-21 induces the release of cytochrome c. MT-21 can be used in the research of tumors. | |||||||||||||||||||||
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References
- [1]. Watabe M, Machida K, Osada H. MT-21 is a synthetic apoptosis inducer that directly induces cytochrome c release from mitochondria. Cancer Res. 2000 Sep 15;60(18):5214-22. [Content Brief]
- [2]. Machida K, et al. A novel adenine nucleotide translocase inhibitor, MT-21, induces cytochrome c release by a mitochondrial permeability transition-independent mechanism. J Biol Chem. 2002 Aug 23;277(34):31243-8. [Content Brief]
