187986-11-4
Chemical Structure
WKYMVM-NH2
- CAS No.: 187986-11-4
- Formula:C41H61N9O7S2
- Molecular Weight:856.11
IUPAC Name: (S)-6-amino-2-((S)-2-amino-3-(1H-indol-3-yl)propanamido)-N-((5S,8S,11S,14S)-5-carbamoyl-15-(4-hydroxyphenyl)-8-isopropyl-11-(2-(methylthio)ethyl)-7,10,13-trioxo-2-thia-6,9,12-triazapentadecan-14-yl)hexanamide
InChIKey: FMBGOORJEKQQLG-LXOXETEGSA-N
SMILES: OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CCSC)C(N[C@@H](C(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)NC([C@H](CCCCN)NC([C@@H](N)CC2=CNC3=CC=CC=C23)=O)=O
Biological Activity: WKYMVM-NH2 is a hexapeptide that activates neutrophils and myeloid cells via the FPRL1 and FPRL2 receptors. It exhibits EC50 values of 2 nM and 80 nM in HL-60-FPRL1 and HL-60-FPRL2 cells, respectively. In HL-60 cells stably expressing FPRL2, WKYMVM-NH₂ induces chemotaxis, with optimal migration observed at concentrations ranging from 10 to 50 nM. It also stimulates superoxide production in neutrophils, with an EC50 of 75 nM. WKYMVM-NH₂ is a useful tool for research in the field of inflammatory diseases[1].
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WKYMVM-NH2 | WKYMVM-NH2 is a hexapeptide that activates neutrophils and myeloid cells via the FPRL1 and FPRL2 receptors. It exhibits EC50 values of 2 nM and 80 nM in HL-60-FPRL1 and HL-60-FPRL2 cells, respectively. In HL-60 cells stably expressing FPRL2, WKYMVM-NH₂ induces chemotaxis, with optimal migration observed at concentrations ranging from 10 to 50 nM. It also stimulates superoxide production in neutrophils, with an EC50 of 75 nM. WKYMVM-NH₂ is a useful tool for research in the field of inflammatory diseases. | |||||||||||||||||||||
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