188240-41-7
Chemical Structure
Maurotoxin
- CAS No.: 188240-41-7
- Formula:C145H232N46O46S8
- Molecular Weight:3612.19
SMILES: O=C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@H]1CO)=O)=O)=O)=O)NC2=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N)=O)NC3=O)C(N[C@@H](CC4=CC=C(C=C4)O)C(NC3)=O)=O)=O)=O)NC1=O)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](C)C(N6[C@@H](CCC6)C(N[C@@H](CSSC[C@@H](C(N7[C@@H](CCC7)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@H]2CCCCN)=O)=O)=O)=O)NC8=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(NC8)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N
Biological Activity: Maurotoxin is a 34-residue and four disulde-bridged toxin that can be isolated from the chactoid scorpion (Scorpio maurus). Maurotoxin inhibits the Shaker potassium channels (ShB) K+ current with an IC50 of 2 nM[1][2].
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Maurotoxin | Maurotoxin is a 34-residue and four disulde-bridged toxin that can be isolated from the chactoid scorpion (Scorpio maurus). Maurotoxin inhibits the Shaker potassium channels (ShB) K+ current with an IC50 of 2 nM. | |||||||||||||||||||||
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References
- [1]. Bende NS, et al. A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a. Nat Commun. 2014 Jul 11;5:4350. [Content Brief]
- [2]. Castle NA, et al. Maurotoxin: a potent inhibitor of intermediate conductance Ca2+-activated potassium channels. Mol Pharmacol. 2003 Feb;63(2):409-18. [Content Brief]
